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Bioorg Med Chem Lett. 2009 Jul 15;19(14):3783-6. doi: 10.1016/j.bmcl.2009.04.071. Epub 2009 Apr 22.

Analysis of HIF-1 inhibition by manassantin A and analogues with modified tetrahydrofuran configurations.

Author information

1
Department of Chemistry, Duke University, Durham, NC 27708, USA.

Abstract

We have shown that manassantin A downregulated the HIF-1alpha expression and inhibited the secretion of VEGF. We have also demonstrated that the 2,3-cis-3,4-trans-4,5-cis-configuration of the tetrahydrofuran is critical to the HIF-1 inhibition of manassantin A.

PMID:
19423348
PMCID:
PMC2709708
DOI:
10.1016/j.bmcl.2009.04.071
[Indexed for MEDLINE]
Free PMC Article

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