Send to

Choose Destination
Am J Transplant. 2009 May;9(5):1223-9. doi: 10.1111/j.1600-6143.2009.02586.x.

Anti-Factor H autoantibodies in a fifth renal transplant recipient with atypical hemolytic and uremic syndrome.

Author information

Université Paris Descartes, Service de Transplantation Rénale et Soins Intensifs, Hôpital Necker, APHP, Paris, France.

Erratum in

  • Am J Transplant. 2009 Sep;9(9):2205. Niauif, P [added].
  • Am J Transplant.2009 Nov;9(11):2647. Niauif, P [corrected to Niaudet, P].


Hemolytic uremic syndrome (HUS) associated with anti-Factor H (anti-FH) autoantibodies is a recently described pathophysiological entity. Monitoring of anti-FH IgG titer may be a sensitive marker of disease activity and guide treatment to eliminate circulating anti-FH antibodies. We report here a case of atypical HUS (aHUS) in which anti-FH autoantibodies were detected during the course of a fifth kidney transplant, 30 years after the first flare of aHUS. This exceptional case suggests that early, specific management based on immunosuppressive therapy and plasma exchanges monitored by anti-FH IgG titer may result in long-term graft survival.

[Indexed for MEDLINE]
Free full text

Supplemental Content

Full text links

Icon for Wiley
Loading ...
Support Center