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Nano Lett. 2009 Jun;9(6):2354-9. doi: 10.1021/nl900872r.

Tissue- and organ-selective biodistribution of NIR fluorescent quantum dots.

Author information

1
Division of Hematology/Oncology, Department of Medicine, Beth Israel Deaconess Medical Center, Boston, Massachusetts 02215, USA.

Abstract

A significant portion of the field of nanomedicine is predicated on being able to target nanoparticles to sites of disease. However, in vivo biodistribution and clearance of nanoparticles are poorly understood. In this study, a novel formulation of near-infrared fluorescent InAs(ZnS) quantum dots was synthesized and coated with a systematically increasing chain length of PEG. We found that varying PEG chain length resulted in major changes in organ/tissue-selective biodistribution and clearance from the body.

PMID:
19422261
PMCID:
PMC2782558
DOI:
10.1021/nl900872r
[Indexed for MEDLINE]
Free PMC Article

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