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Macromol Biosci. 2009 Sep 9;9(9):842-8. doi: 10.1002/mabi.200800367.

Preparation of size tunable amphiphilic poly(amino acid) nanoparticles.

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Department of Applied Chemistry, Graduate School of Engineering, Osaka University, 2-1 Yamadaoka, Suita 565-0871, Japan.


Size tunable amphiphilic NPs composed of poly(gamma-PGA) and hydrophobic amino acids, such as Phe or Trp, were prepared. To prepare these size-regulated NPs, gamma-PGA-g-Phe or gamma-PGA-g-Trp dissolved in DMSO was added to various concentrations of NaCl solution. The gamma-PGA-Phe and gamma-PGA-Trp formed monodispersed NPs, and the size of NPs can be easily controlled by NaCl concentration. The different-sized NPs showed the same structure. The encapsulation of protein into the different-sized NPs was successfully achieved and the size of protein-encapsulated gamma-PGA-Phe NPs was increased when protein was encapsulated.

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