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Chembiochem. 2009 May 25;10(8):1321-4. doi: 10.1002/cbic.200900132.

[18F]SiFA-isothiocyanate: a new highly effective radioactive labeling agent for lysine-containing proteins.

Author information

1
Montreal Neurological Institute, McGill University, Douglas Research Institute, Montreal, H3A 2B4, Canada.

Abstract

A highly efficient (18)F-labeling synthon for universal protein labeling is reported. Diverse (18)F-labeled proteins of 66-144 kDa were prepared with [(18)F]SiFA-isothiocyanate synthesized by an isotopic (19)F for (18)F exchange at the silicon atom. Overall preparative radiochemical yields were 20-40 % after 40-50 min. No bone uptake of (18)F radioactivity was detected until 90 min post-injection of (18)F-SiFA-RSA; this demonstrates the metabolic stability of the [(18)F]SiFA moiety.

PMID:
19422010
DOI:
10.1002/cbic.200900132
[Indexed for MEDLINE]

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