Send to

Choose Destination
See comment in PubMed Commons below
Opt Express. 2001 Sep 10;9(6):272-86.

Three-dimensional optical tomography of hemodynamics in the human head.


We report on the first three-dimensional, volumetric, tomographic localization of vascular reactivity in the brain. To this end we developed a model-based iterative image reconstruction scheme that employs adjoint differentiation methods to minimize the difference between measured and predicted data. The necessary human-head geometry and optode locations were determined with a photogrammetric method. To illustrate the performance of the technique, the three-dimensional distribution of changes in the concentration of oxyhemoglobin, deoxyhemoglobin, and total hemoglobin during a Valsalva maneuver were visualized. The observed results are consistent with previously reported effects concerning optical responses to hemodynamic perturbations.

PubMed Commons home

PubMed Commons

How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Optical Society of America
    Loading ...
    Support Center