Format

Send to

Choose Destination
Chem Pharm Bull (Tokyo). 2009 May;57(5):476-80.

Synthesis and DNA polymerase alpha and beta inhibitory activity of alkyl p-coumarates and related compounds.

Author information

1
Kobe Pharmaceutical University, Kobe, Japan. nishi@kobepharma-u.ac.jp

Abstract

trans- and cis-Icosyl, docosyl, and tetracosyl p-coumarates, constituents of Artemisia annua L., and their structurally-related compounds were synthesized and evaluated for inhibitory activity on DNA polymerases alpha and beta. Among 30 compounds synthesized, octadecyl trans- and cis-p-coumarates and octadecyl p-hydroxyphenylpropiolate showed strong inhibitory activity on DNA polymerases alpha and beta.

PMID:
19420778
DOI:
10.1248/cpb.57.476
[Indexed for MEDLINE]
Free full text

Supplemental Content

Full text links

Icon for J-STAGE, Japan Science and Technology Information Aggregator, Electronic
Loading ...
Support Center