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Pediatr Blood Cancer. 2009 Sep;53(3):499-501. doi: 10.1002/pbc.22005.

Bronchioloalveolar carcinoma as a second malignancy in osteosarcoma survivors.

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  • 1Department of Oncology, St. Jude Children's Research Hospital, Memphis, Tennessee 38105, USA.


Second malignancies occur in 2-3% of survivors of pediatric osteosarcoma; treatment-related hematologic and solid malignancies have both been described. We present two cases of patients with pulmonary nodules that developed more than 2 years after treatment of osteosarcoma. Both lesions were completely resected and pathology revealed bronchioloalveolar carcinoma (BAC). Primary BAC is extremely rare in children; however, cases of this malignancy have been described in survivors of pediatric cancer. BAC may present as a solitary pulmonary nodule indistinguishable from a metastatic lesion and should be included in the differential diagnosis of pulmonary nodules in survivors of pediatric cancer.

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