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Nature. 1977 Apr 28;266(5605):815-9.

Defective interfering particles with covalently linked [+/-]RNA induce interferon.

Abstract

Defective interfering (DI) particles of vesicular stomatitis virus which contain covalently linked complementary [+]message and [-]anti-message RNA as a single-stranded ribonucleoprotein complex within the particle, are extremely efficient inducers of interferon. A single particle can induce a quantum yield of interferon. A single molecule of double-stranded RNA presumed to form, at least in part, on entry into the cell is thought to induce interferon synthesis. Conventional [-]RNA DI particles with the same polypeptide composition as [+/-]RNA DI particles fail to induce interferon.

PMID:
194158
DOI:
10.1038/266815a0
[Indexed for MEDLINE]

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