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In Vivo. 2009 Mar-Apr;23(2):287-9.

Potentiating effect of Mentha arvensis and chlorpromazine in the resistance to aminoglycosides of methicillin-resistant Staphylococcus aureus.

Author information

1
Laboratory of Research in Natural Products, Department of Biological Chemistry, Center of Biological Sciences and Health, University of the Region of Cariri, Crato, Brazil. hdmcoutinho@gmail.com

Abstract

BACKGROUND:

This is the first report testing the antibiotic resistance-modifying activity of Mentha arvensis against MRSA (methicillin-resistant Staphylococcus aureus).

MATERIALS AND METHODS:

In this study an ethanol extract of Mentha arvensis L. and chlorpromazine were tested for their antimicrobial activity alone or in combination with conventional antibiotics against MRSA strains.

RESULTS:

A potentiating effect of this extract on gentamicin, kanamycin and neomycin was demonstrated. Similarly, a potentiating effect of chlorpromazine on the same aminoglycosides was observed, indicating the involvement of an efflux system in the resistance to these antibiotics.

CONCLUSION:

It is therefore suggested that extracts from M. arvensis could be used as a source of plant-derived natural products with resistance-modifying activity, such as in the case of aminoglycosides, constituting a new weapon against bacterial resistance to antibiotics, as with chlorpromazine.

PMID:
19414416
[Indexed for MEDLINE]
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