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Bioorg Med Chem Lett. 2009 Jun 1;19(11):2920-3. doi: 10.1016/j.bmcl.2009.04.076. Epub 2009 Apr 22.

Structural insight into human CK2alpha in complex with the potent inhibitor ellagic acid.

Author information

1
Graduate School of Science, Osaka Prefecture University, Sakai, Osaka, Japan.

Abstract

We determined the 2.35-A crystal structure of a human CK2 catalytic subunit (referred to as CK2alpha complexed with the ATP-competitive, potent CK2 inhibitor ellagic acid. The inhibitor binds to CK2alpha with a novel binding mode, including water-mediated hydrogen bonds. This structural information may support discovery of potent CK2 inhibitors.

PMID:
19414254
DOI:
10.1016/j.bmcl.2009.04.076
[Indexed for MEDLINE]

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