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Br J Pharmacol. 2009 May;157(1):14-23. doi: 10.1111/j.1476-5381.2009.00250.x.

Molecular and biochemical pharmacology of the histamine H4 receptor.

Author information

1
Department of Medicinal Chemistry, Leiden/Amsterdam Center for Drug Research, VU University Amsterdam, Amsterdam, The Netherlands. leurs@few.vu.nl

Abstract

The elucidation of the human genome has had a major impact on histamine receptor research. The identification of the human H4 receptor by several groups has been instrumental for a new appreciation of the role of histamine in the modulation of immune function. In this review, we summarize the historical developments and the molecular and biochemical pharmacology of the H4 receptor.

PMID:
19413568
PMCID:
PMC2697796
DOI:
10.1111/j.1476-5381.2009.00250.x
[Indexed for MEDLINE]
Free PMC Article

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