Abstract
Tetramic acid derivatives are an important class of nitrogen heterocycles with a pyrrolidine-2,4-dione core as a key structural motif. From the sponge-derived fungus Beauveria bassiana, a new equisetin-like tetramic acid derivative, beauversetin (1), was isolated. The sea weed-derived fungus Microdiplodia sp. produced the tetramic acid derivative 2 (Sch210972) which was shown to inhibit human leucocyte elastase (HLE) with an IC50 of 1.04 microg mL(-1).
Publication types
-
Research Support, Non-U.S. Gov't
MeSH terms
-
Animals
-
Cyclic N-Oxides / analysis*
-
Cyclic N-Oxides / isolation & purification*
-
Cyclic N-Oxides / toxicity
-
Hypocreales / chemistry*
-
Leukocyte Elastase / drug effects
-
Magnetic Resonance Spectroscopy
-
Molecular Structure
-
Porifera / microbiology*
-
Pyrrolidinones / analysis*
-
Pyrrolidinones / chemistry
-
Pyrrolidinones / isolation & purification*
-
Pyrrolidinones / toxicity
Substances
-
Cyclic N-Oxides
-
Pyrrolidinones
-
tetramic acid
-
Leukocyte Elastase