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Hypertens Pregnancy. 2009;28(3):300-11. doi: 10.1080/10641950802601237.

Preeclampsia is associated with lower percentages of regulatory T cells in maternal blood.

Author information

1
University Medical Center Groningen, Department of Obstetrics and Gynaecology, Groningen, Netherlands.

Abstract

OBJECTIVE:

Immunological mechanisms are involved in the pathophysiology of preeclampsia. During pregnancy there is an increase in regulatory T (Treg) cells, which has an important role in regulating tolerance to the immunologically distinct fetus. We hypothesised that percentages of Treg cells are decreased in preeclamptic patients.

METHODS:

Peripheral blood was obtained from 26 healthy pregnant controls and 18 preeclamptic patients. Treg cells were measured using flow-cytometry.

RESULTS:

Women with pregnancies complicated by preeclampsia had significantly lower percentages of CD4(+)FOXP3(+) Treg cells.

CONCLUSION:

We conclude that a deficiency of regulatory T cells may play a role in the pathophysiology of preeclampsia.

PMID:
19412837
DOI:
10.1080/10641950802601237
[Indexed for MEDLINE]

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