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Comp Biochem Physiol C Toxicol Pharmacol. 2009 Aug;150(2):218-23. doi: 10.1016/j.cbpc.2009.04.009. Epub 2009 May 3.

Biochemical changes in rockfish, Sebastes schlegeli, exposed to dispersed crude oil.

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  • 1Oil and POPs Research Group, KORDI, Geoje-shi, 656-834, Republic of Korea.


This paper describes the response of the ovoviviparous rockfish, Sebastes schlegeli, to hydrocarbons in the water-accommodated fraction (WAF) of crude oil, in the presence or absence of oil dispersants. Concentrations of cytochrome P-450 1A (CYP1A) and levels of its catalytic activity ethoxyresorufin O-de-ethylase (EROD) in rockfish exposed to WAF at concentrations of 0.1% and 1% were significantly increased by the addition of a dispersant, Corexit 9500 after 48 h exposure. After 72 h exposure, the levels of CYP1A and EROD activity were significantly increased in 0.1% and 0.01% chemically enhanced WAF (CEWAF) (Corexit 9500 and Hiclean II dispersant). Bile samples from fish exposed to WAF alone had low concentrations of hydrocarbon metabolites, exemplified by 1-hydroxypyrene. After 72 h exposure, hydrocarbon metabolites in bile from fish exposed to WAF in the presence of either Corexit 9500 or Hiclean II were significantly higher compared with fish exposed to WAF alone or control fish. These experiments confirm that the use of oil dispersants will increase the exposure of ovoviviparous fish to hydrocarbons in oil.

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