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Med Hypotheses. 2009 Aug;73(2):220-9. doi: 10.1016/j.mehy.2009.02.039. Epub 2009 May 1.

Neuroscientific psychiatric diagnosis.

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Bruce and Ruth Rappaport Faculty of Medicine, Technion - Israel Institute of Technology Haifa, POB 43, 30550 Binyamina, Israel.


The DSM is not brain-related and is thus unable to relate clinical assessments to putative brain disturbances. 'Clinical brain profiling' (CBP) involves the rearrangement of clinical findings to assess the relevant disturbances in brain dynamics. CBP has three major pathological dimensions, (1) disorders of basic brain organization and development (2) disorders of connectivity dynamics and balance and (3) disorders of plasticity dynamics and neural resilience. CBP is a useful platform for the development of a brain-related neuroscientific diagnosis for psychiatry. Once the underlying pathology of a mental disorder is known an effective intervention can be designed to cure the disorder.

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