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Regul Pept. 2009 Aug 7;156(1-3):24-7. doi: 10.1016/j.regpep.2009.04.011. Epub 2009 May 3.

Peripheral mechanisms in the control of appetite and related experimental therapies in obesity.

Author information

1
Clinical Enteric Neuroscience Translational and Epidemiological Research (CENTER), College of Medicine, Mayo Clinic, Rochester, Minnesota, United States. camilleri.michael@mayo.edu

Abstract

The function of the stomach and the gut hormonal responses to food ingestion constitute highly integrated homeostatic responses that maintain euglycemia and normal digestion. This intrinsic feedback involves vagal and hormonal mechanisms. Important signals such as GLP-1 and PYY that arise peripherally induce satiation and also delay gastric emptying or increase insulin secretion. Novel therapies are being developed to mimic or enhance these feedback mechanisms and to control appetite as a means to treat obesity.

PMID:
19409936
PMCID:
PMC3898935
DOI:
10.1016/j.regpep.2009.04.011
[Indexed for MEDLINE]
Free PMC Article

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