Format

Send to

Choose Destination
See comment in PubMed Commons below
Trends Neurosci. 2009 Jun;32(6):312-20. doi: 10.1016/j.tins.2009.02.004. Epub 2009 May 4.

From high anxiety trait to depression: a neurocognitive hypothesis.

Author information

1
Laboratory of Behavioral Genetics, Brain Mind Institute, Ecole Polytechnique Federale de Lausanne (EPFL), Lausanne CH-1015, Switzerland. carmen.sandi@epfl.ch

Abstract

Although exposure to substantial stress has a major impact on the development of depression, there is considerable variability in the susceptibility of individuals to the adverse effects of stress. The personality trait of high anxiety has been identified as a vulnerability factor to develop depression. We propose here a new unifying model based on a series of neurocognitive mechanisms (and fed with crucial information provided by research on the fields of emotion, stress and cognition) whereby individuals presenting a high anxiety trait are particularly vulnerable to develop depression when facing stress and adversity. Our model highlights the importance of developing prevention programs addressed to restrain, in high anxious individuals, the triggering of a dysfunctional neurocognitive cascade while coping with stress.

PMID:
19409624
DOI:
10.1016/j.tins.2009.02.004
[Indexed for MEDLINE]
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Elsevier Science
    Loading ...
    Support Center