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Neuron. 2009 Apr 30;62(2):291-303. doi: 10.1016/j.neuron.2009.03.012.

State-dependent variability of neuronal responses to transcranial magnetic stimulation of the visual cortex.

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1
Helen Wills Neuroscience Institute, University of California, Berkeley, Berkeley, CA 94720, USA.

Abstract

Electrical brain stimulation is a promising tool for both experimental and clinical applications. However, the effects of stimulation on neuronal activity are highly variable and poorly understood. To investigate the basis of this variability, we performed extracellular recordings in the visual cortex following application of transcranial magnetic stimulation (TMS). Our measurements of spiking and local field potential activity exhibit two types of response patterns which are characterized by the presence or absence of spontaneous discharge following stimulation. This variability can be partially explained by state-dependent effects, in which higher pre-TMS activity predicts larger post-TMS responses. These results reveal the possibility that variability in the neural response to TMS can be exploited to optimize the effects of stimulation. It is conceivable that this feature could be utilized in real time during the treatment of clinical disorders.

PMID:
19409273
PMCID:
PMC2953477
DOI:
10.1016/j.neuron.2009.03.012
[Indexed for MEDLINE]
Free PMC Article
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