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Neuron. 2009 Apr 30;62(2):171-89. doi: 10.1016/j.neuron.2009.04.008.

Rapid neocortical dynamics: cellular and network mechanisms.

Author information

1
Department of Neurobiology, Kavli Institute for Neuroscience, Yale University School of Medicine, 333 Cedar Street, New Haven, CT 06510, USA.

Abstract

The highly interconnected local and large-scale networks of the neocortical sheet rapidly and dynamically modulate their functional connectivity according to behavioral demands. This basic operating principle of the neocortex is mediated by the continuously changing flow of excitatory and inhibitory synaptic barrages that not only control participation of neurons in networks but also define the networks themselves. The rapid control of neuronal responsiveness via synaptic bombardment is a fundamental property of cortical dynamics that may provide the basis of diverse behaviors, including sensory perception, motor integration, working memory, and attention.

PMID:
19409263
PMCID:
PMC3132648
DOI:
10.1016/j.neuron.2009.04.008
[Indexed for MEDLINE]
Free PMC Article

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