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Nano Lett. 2009 Jun;9(6):2280-4. doi: 10.1021/nl900437n.

Functionalized carbon nanotubes specifically bind to alpha-chymotrypsin's catalytic site and regulate its enzymatic function.

Author information

1
School of Chemistry and Chemical Engineering, Shandong University, Jinan 250100, China.

Abstract

Although carbon nanotubes (CNTs) have been shown to nonspecifically bind proteins through charge complementary, pi-pi stacking or hydrophobic interactions, they have not been shown to bind to a specific site on proteins. By generating surface molecular diversity, we created functionalized CNTs that recognize and bind to the catalytic site of alpha-chymotrypsin and inhibit its enzymatic activity competitively.

PMID:
19408924
PMCID:
PMC2814308
DOI:
10.1021/nl900437n
[Indexed for MEDLINE]
Free PMC Article
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