Abstract
A new fluorenone alkaloid (caulophine) was isolated from the radix of Caulophyllum robustum Maxim. (collected from the Qinling mountains) using cell membrane chromatography as the screening method. Caulophine was identified as 3-(2-(dimethylamino)ethyl)-4,5-dihydroxy-1,6-dimethoxy-9H-fluoren-9-one based on physicochemic and spectroscopic analyses, particularly by NMR spectroscopic data (i.e., COSY, HMQC, HMBC, NOESY). Caulophine possessed anti-myocardial ischemia activity.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Alkaloids / chemistry
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Alkaloids / isolation & purification
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Alkaloids / pharmacology*
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Animals
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Cardiovascular Agents / chemistry
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Cardiovascular Agents / isolation & purification
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Cardiovascular Agents / pharmacology*
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Caulophyllum* / chemistry
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Chromatography / methods
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Disease Models, Animal
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Fluorenes / chemistry
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Fluorenes / isolation & purification
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Fluorenes / pharmacology*
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Magnetic Resonance Spectroscopy
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Male
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Molecular Structure
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Myocardial Infarction / pathology
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Myocardial Infarction / prevention & control*
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Myocardial Ischemia / pathology
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Myocardial Ischemia / prevention & control*
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Rats
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Rats, Sprague-Dawley
Substances
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Alkaloids
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Cardiovascular Agents
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Fluorenes