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Nature. 2009 Apr 30;458(7242):1127-30. doi: 10.1038/nature07986.

Cytoplasmic functions of the tumour suppressor p53.

Author information

1
Department of Immunology, St Jude Children's Research Hospital, Memphis, Tennessee 38105, USA. douglas.green@stjude.org

Abstract

The principal tumour-suppressor protein, p53, accumulates in cells in response to DNA damage, oncogene activation and other stresses. It acts as a nuclear transcription factor that transactivates genes involved in apoptosis, cell cycle regulation and numerous other processes. An emerging area of research unravels additional activities of p53 in the cytoplasm, where it triggers apoptosis and inhibits autophagy. These previously unknown functions contribute to the mission of p53 as a tumour suppressor.

PMID:
19407794
PMCID:
PMC2814168
DOI:
10.1038/nature07986
[Indexed for MEDLINE]
Free PMC Article

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