Format

Send to

Choose Destination
Curr Opin Struct Biol. 2009 Jun;19(3):357-62. doi: 10.1016/j.sbi.2009.03.008. Epub 2009 May 4.

The sequence-structure relationship and protein function prediction.

Author information

1
Division of Mathematical Biology, National Institute for Medical Research, The Ridgeway, Mill Hill, London NW7 1AA UK.

Abstract

An incomplete understanding of protein sequence/structure/function relationships causes many difficulties for prediction methods. The highly complex nature of these relationships is a consequence of the interplay between physics and evolution that has been studied using a wide array of experimental and theoretical techniques. We review recent findings relating to conservation of sequence, structure and function and discuss their use in developing improved prediction methods.

PMID:
19406632
DOI:
10.1016/j.sbi.2009.03.008
[Indexed for MEDLINE]

Supplemental Content

Full text links

Icon for Elsevier Science
Loading ...
Support Center