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Biochim Biophys Acta. 2009 Dec;1796(2):201-15. doi: 10.1016/j.bbcan.2009.04.005. Epub 2009 May 4.

Translocations in epithelial cancers.

Author information

1
Michigan Center for Translational Pathology, University of Michigan, 1400 E. Medical Center Drive, 5316 CCGC, Ann Arbor, MI 48109, USA.

Abstract

Genomic translocations leading to the expression of chimeric transcripts characterize several hematologic, mesenchymal and epithelial malignancies. While several gene fusions have been linked to essential molecular events in hematologic malignancies, the identification and characterization of recurrent chimeric transcripts in epithelial cancers has been limited. However, the recent discovery of the recurrent gene fusions in prostate cancer has sparked a revitalization of the quest to identify novel rearrangements in epithelial malignancies. Here, the molecular mechanisms of gene fusions that drive several epithelial cancers and the recent technological advances that increase the speed and reliability of recurrent gene fusion discovery are explored.

PMID:
19406209
PMCID:
PMC2752494
DOI:
10.1016/j.bbcan.2009.04.005
[Indexed for MEDLINE]
Free PMC Article

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