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Am J Vet Res. 2009 May;70(5):614-8. doi: 10.2460/ajvr.70.5.614.

Pancreatic response in healthy dogs fed diets of various fat compositions.

Author information

1
Department of Veterinary Clinical Sciences, Murdoch University, Perth, WA, Australia 6150.

Abstract

OBJECTIVE:

To indirectly assess the pancreatic response in healthy dogs that were fed diets of different fat compositions with or without supplemental pancreatic enzymes and medium-chain triglycerides (MCTs).

ANIMALS:

10 healthy adult dogs.

PROCEDURES:

Dogs were fed 4 diets once in random order at 1-week intervals; food was withheld from the dogs for > or = 12 hours prior to the feeding of each diet. Diets A and B contained 16% and 5% crude fat, respectively; diet C was composed of diet A with pancreatic enzymes; and diet D was composed of diet B with pancreatic enzymes and MCTs. Serum canine trypsin-like immunoreactivity (cTLI) and canine pancreatic lipase immunoreactivity (cPLI) concentrations were measured before (0 hours) and at 1 to 2 and 6 hours after feeding. Serum gastrin concentration was measured at 0 hours and at 5 to 10 minutes and 1 to 2 hours after feeding. A gastrin assay validation study was performed to confirm accuracy of test results in dogs. Data were analyzed by use of a repeated-measures general ANOVA.

RESULTS:

Serum cTLI, cPLI, or gastrin concentrations in the dogs did not differ among the different diets fed, among dogs, or over time. When multiple comparisons were analyzed, diet D caused the least amount of measurable pancreatic response, although this difference was not significant.

CONCLUSIONS AND CLINICAL RELEVANCE:

Results did not indicate a significant effect of dietary fat content or addition of supplemental MCT oil or pancreatic enzymes in diets on serum cTLI, cPLI, or gastrin concentrations in healthy dogs.

PMID:
19405900
DOI:
10.2460/ajvr.70.5.614
[Indexed for MEDLINE]

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