Format

Send to

Choose Destination
See comment in PubMed Commons below
Hippocampus. 2009 Jun;19(6):588-95. doi: 10.1002/hipo.20613.

Parametric surface modeling and registration for comparison of manual and automated segmentation of the hippocampus.

Author information

  • 1Division of Imaging Sciences, Department of Radiology, IU Center for Neuroimaging, Indiana University School of Medicine, Indianapolis, Indiana 46202, USA. shenli@iupui.edu

Abstract

Accurate and efficient segmentation of the hippocampus from brain images is a challenging issue. Although experienced anatomic tracers can be reliable, manual segmentation is a time consuming process and may not be feasible for large-scale neuroimaging studies. In this article, we compare an automated method, FreeSurfer (V4), with a published manual protocol on the determination of hippocampal boundaries from magnetic resonance imaging scans, using data from an existing mild cognitive impairment/Alzheimer's disease cohort. To perform the comparison, we develop an enhanced spherical harmonic processing framework to model and register these hippocampal traces. The framework treats the two hippocampi as a single geometric configuration and extracts the positional, orientation, and shape variables in a multiobject setting. We apply this framework to register manual tracing and FreeSurfer results together and the two methods show stronger agreement on position and orientation than shape measures. Work is in progress to examine a refined FreeSurfer segmentation strategy and an improved agreement on shape features is expected.

PMID:
19405146
PMCID:
PMC2849649
DOI:
10.1002/hipo.20613
[PubMed - indexed for MEDLINE]
Free PMC Article
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Wiley Icon for PubMed Central
    Loading ...
    Support Center