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Acta Orthop. 2009 Apr;80(2):201-4. doi: 10.3109/17453670902930032.

Poor results of drilling in early stages of juxta-articular osteonecrosis in 12 joints affected by Gaucher disease.

Author information

1
Department of Orthopaedic Surgery, Shaare Zedek Medical Center, Jerusalem, Israel.

Abstract

BACKGROUND AND PURPOSE:

Gaucher disease is heterogeneous. One of the most devastating complications is bone involvement, ranging from mild osteopenia to osteonecrosis, but no markers have been discovered to predict onset and/or progression. We describe our experience in a large referral center using drilling for juxta-articular osteonecrosis in young patients with Gaucher disease.

PATIENTS AND METHODS:

We retrospectively reviewed medical data from all patients who were recommended to undergo drilling for osteonecrosis of juxta-articular bone of the femoral head, the humeral head, or upper tibia for acute osteonecrosis at a pre-collapse stage.

RESULTS:

11 patients (mean age 34 years) underwent drilling of 12 joints with juxta-articular osteonecrosis; 3 (mean age 51 years) refused intervention. 9 joints that were drilled showed advancing joint degeneration within 0.5 to 4 years. 3 joints have undergone replacement. Of the 3 joints that did not undergo drilling, 2 have undergone replacement and 1 has collapsed with osteoarthritis.

INTERPRETATION:

We found equally poor outcome with and without drilling. Effective intervention can only be achieved by improving our understanding of bone physiology and pathophysiology in Gaucher disease.

PMID:
19404804
PMCID:
PMC2823173
DOI:
10.3109/17453670902930032
[Indexed for MEDLINE]
Free PMC Article
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