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J Infect Dis. 1991 Nov;164(5):962-4.

Lack of detection of human immunodeficiency virus in persistently seronegative homosexual men with high or medium risks for infection.

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Department of Medicine, School of Medicine, University of California, San Francisco 94143.


Some studies have suggested that seronegative homosexual men who have practiced high-risk sexual behavior can carry the human immunodeficiency virus (HIV) in a silent state, detectable only by polymerase chain reaction (PCR) or selective viral culture. To assess this concept, blood specimens were studied from 59 homosexual men with recognized risk behaviors: unprotected anal receptive intercourse at least once and many lifetime sex partners. After extensive virologic studies and PCR analysis, only one virus-positive, antibody-negative individual was identified. These findings indicate that HIV virus-positive, seronegative individuals are rare.

[Indexed for MEDLINE]

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