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Nat Cell Biol. 2009 May;11(5):536-8. doi: 10.1038/ncb0509-536.

Breaking a temporal barrier: signalling crosstalk regulates the initiation of border cell migration.

Abstract

Correct timing of developmental events is crucial for generating a normal organism. During oogenesis in Drosophila melanogaster, migration of border cells occurs in a defined temporal window and requires Jak/Stat and steroid hormone signalling. The initiation of border-cell migration is now shown to be timed by Jak/Stat-mediated downregulation of the BTB domain transcriptional regulator Abrupt, which acts as a negative regulator of steroid hormone signalling.

PMID:
19404334
DOI:
10.1038/ncb0509-536
[Indexed for MEDLINE]

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