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J Physiol. 2009 Jul 1;587(Pt 13):3071-9. doi: 10.1113/jphysiol.2009.171876. Epub 2009 Apr 29.

Minor sarcoplasmic reticulum membrane components that modulate excitation-contraction coupling in striated muscles.

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1
Departments of Anesthesia and Biomedicine, Basel University Hospital, Switzerland.

Abstract

In striated muscle, activation of contraction is initiated by membrane depolarisation caused by an action potential, which triggers the release of Ca(2+) stored in the sarcoplasmic reticulum by a process called excitation-contraction coupling. Excitation-contraction coupling occurs via a highly sophisticated supramolecular signalling complex at the junction between the sarcoplasmic reticulum and the transverse tubules. It is generally accepted that the core components of the excitation-contraction coupling machinery are the dihydropyridine receptors, ryanodine receptors and calsequestrin, which serve as voltage sensor, Ca(2+) release channel, and Ca(2+) storage protein, respectively. Nevertheless, a number of additional proteins have been shown to be essential both for the structural formation of the machinery involved in excitation-contraction coupling and for its fine tuning. In this review we discuss the functional role of minor sarcoplasmic reticulum protein components. The definition of their roles in excitation-contraction coupling is important in order to understand how mutations in genes involved in Ca(2+) signalling cause neuromuscular disorders.

PMID:
19403606
PMCID:
PMC2727015
DOI:
10.1113/jphysiol.2009.171876
[Indexed for MEDLINE]
Free PMC Article
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