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Phys Med Biol. 2009 May 21;54(10):N177-88. doi: 10.1088/0031-9155/54/10/N01. Epub 2009 Apr 27.

Development of a remanence measurement-based SQUID system with in-depth resolution for nanoparticle imaging.

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1
Department of Physics, University of Michigan, Ann Arbor, MI 48109, USA.

Abstract

We present a remanence measurement method using a superconducting quantum interference device (SQUID) to detect trace amounts of magnetic nanoparticles (MNPs). Based on this method, a one-dimensional scanning system was established for imaging. The system was calibrated with 25 nm diameter Fe2O3 nanoparticles (NPs), and the sensitivity of the NPs was found to be 10 ng at a distance of 1.7 cm and the spatial resolution was approximately 1 cm. A theoretical model of this system was developed and applied to the deconvolution of scanned images of phantoms with two NP injection spots. Using the developed SQUID system, we were able to determine not only the amount and horizontal positions of the injections, but also their depths in the phantoms.

PMID:
19398816
PMCID:
PMC2726008
DOI:
10.1088/0031-9155/54/10/N01
[Indexed for MEDLINE]
Free PMC Article
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