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Angiology. 2010 Feb;61(2):198-204. doi: 10.1177/0003319709333869. Epub 2009 Apr 26.

Is inflammatory bowel disease a risk factor for early atherosclerosis?

Author information

1
Department of Cardiology, First University, Medical School, Elaziğ, Turkey. mustafanecati46@hotmail.com

Abstract

OBJECTIVES:

Chronic inflammatory diseases are associated with an accelerated atherosclerotic process. Recent studies have discussed whether inflammatory bowel diseases (IBDs) can predict early atherosclerosis. We investigated this possibility.

METHODS:

The study consisted of IBD cases (group 1, n = 40) and healthy persons (group 2, n = 40). The IBD group was selected so as not to have vascular disease or the presence of established major cardiovascular risk factors.

RESULTS:

Group 1 cases showed a significant increase in carotid intima media thickness (cIMT; P = .01). Carotid artery stiffness was impaired in group 1 (P = .03) and high-sensitivity C-reactive protein (hsCRP), homeostasis model assessment of insulin resistance (HOMA-IR), and homocysteine (Hyc) were higher in group 1 patients (P = .02, P = .03, P = .05).

CONCLUSIONS:

Inflammatory bowel disease patients have an increased risk of early atherosclerosis as shown by greater values of cIMT, carotid artery stiffness, Hyc, hsCRP, and insulin resistance.

PMID:
19398421
DOI:
10.1177/0003319709333869
[Indexed for MEDLINE]
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