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Trends Neurosci. 2009 Jun;32(6):303-11. doi: 10.1016/j.tins.2009.01.008. Epub 2009 May 3.

Common astrocytic programs during brain development, injury and cancer.

Author information

1
The Evelyn F. and William L. McKnight Brain Institute, The University of Florida, 100 South Newell Drive, P.O. Box 100015, Gainesville, FL 32610-0015, USA.

Abstract

In addition to radial glial cells of neurohistogenesis, immature astrocytes with stem-cell-like properties cordon off emerging functional patterns in the developing brain. Astrocytes also can be stem cells during adult neurogenesis, and a proposed potency of injury-associated reactive astrocytes has recently been substantiated. Astrocytic cells might additionally be involved in cancer stem cell-associated gliomagenesis. Thus, there are distinguishing roles for stem-cell-like astrocytes during brain development, in neurogenic niches in the adult, during attempted reactive neurogenesis after brain injury or disease and during brain tumorigenesis.

PMID:
19398132
PMCID:
PMC3033226
DOI:
10.1016/j.tins.2009.01.008
[Indexed for MEDLINE]
Free PMC Article

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