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Androgens and hair loss.

Author information

1
Department of Dermatology and Skin Science, University of British Columbia, British Columbia, Canada.

Abstract

PURPOSE OF REVIEW:

Androgenetic alopecia (AGA) or male pattern hair loss is a very common condition that has a significant psychosocial impact for patients. Many advances in the pathogenesis and treatment of AGA have been discovered recently. We discuss the pathogenesis and treatment of AGA.

RECENT FINDINGS:

Wide genome analysis showed an association of AGA and chromosome 20pll in addition to androgen-receptor gene. Also, a locus on chromosome 3q26 was found to have a linkage with AGA. Dutasteride has been shown to be more effective than finasteride in the treatment of AGA but is not yet a recommended therapy. In an in-vitro study, a new topical liposomal finasteride formulation showed more than five-fold higher deposition of drug in skin than the corresponding plain drug solution.

SUMMARY:

These recent developments in the field of AGA hold some promise and may play a role in the future management.

PMID:
19396986
DOI:
10.1097/med.0b013e32832b100a
[Indexed for MEDLINE]

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