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Autophagy. 2009 Jul;5(5):725-6. Epub 2009 Jul 22.

Rapamycin inhibits mTORC1, but not completely.

Author information

1
Whitehead Institute for Biomedical Research, Cambridge, MA, USA.

Abstract

Rapamycin is widely used as a complete inhibitor of the mTORC1 nutrient-sensitive signaling complex. Using a novel ATP-competitive inhibitor named Torin1, we have found that many mTORC1 functions that regulate cap-dependent translation and autophagy are resistant to inhibition by rapamycin.

PMID:
19395872
[Indexed for MEDLINE]

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