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Diagn Microbiol Infect Dis. 2009 Jul;64(3):350-3. doi: 10.1016/j.diagmicrobio.2009.03.015. Epub 2009 Apr 22.

Development of a 1-step cell-based assay for cost-effective screening of antiviral drugs for vaccinia virus.

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  • 1Instituto de Biofísica Carlos Chagas Filho, Universidade Federal do Rio de Janeiro, Ilha do Fundão, Brazil.


We report a 1-step assay to screen antiviral substances combining the simultaneous application of cells, virus sample, and drug to 96-well plates. The results were obtained within 26 h when vaccinia virus plaques were counted or virus-induced cytopathic effect was measured. This fast cost-effective procedure may be used for other cytopathic viruses and is suitable to 1st screening tests.

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