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Otolaryngol Head Neck Surg. 2009 May;140(5):748-51. doi: 10.1016/j.otohns.2009.01.027. Epub 2009 Mar 17.

The comparison of histopathological characteristics of polyps in asthmatic and nonasthmatic patients.

Author information

1
Tehran University of Medical Sciences, Tehran, Iran.

Abstract

INTRODUCTION:

Considering the different clinical aspects of polyps in asthmatic and nonasthmatic patients, we aimed to explore their histopathological characteristics.

MATERIAL AND METHODS:

Twenty-five asthmatic patients and 25 nonasthmatic patients with polypoid chronic rhinosinusitis (29 male, 21 female; mean age 41.3 +/- 13.27; range 15-78 years) were enrolled in the study to be compared on the basis of histopathological characteristics. They were compared according to the following seven light microscopic findings: basement membrane thickness, goblet cell hyperplasia, subepithelial edema, submucous gland formation, eosinophilic infiltration, lymphocytic infiltration, and polymorphonuclear infiltration.

RESULTS:

Basement membrane thickening, goblet cell hyperplasia, and eosinophilic and lymphocytic infiltration were more prominent in the asthmatic compared with the nonasthmatic group (P < 0.05), whereas polymorphonuclear infiltration was more prominent in nonasthmatics (P < 0.05). No statistically significant differences were found between the two groups with regard to submucosal gland hyperplasia or subepithelial edema.

CONCLUSION:

Asthmatic patients present histopathological characteristics of a marked chronic inflammatory reaction, which might explain the negative effect on chronic rhinosinusitis outcome and the severity of the disease in this group.

PMID:
19393423
DOI:
10.1016/j.otohns.2009.01.027
[Indexed for MEDLINE]

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