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Food Chem Toxicol. 2009 Jul;47(7):1653-8. doi: 10.1016/j.fct.2009.04.013. Epub 2009 Apr 22.

Induction of apoptosis by phloroglucinol derivative from Ecklonia Cava in MCF-7 human breast cancer cells.

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1
Marine Bioprocess Research Center, Pukyong National University, Busan 608-737, Republic of Korea.

Abstract

Phloroglucinol derivatives, dioxinodehydroeckol (1) and 1-(3',5'-dihydroxyphenoxy)-7-(2'',4'',6-trihydroxyphenoxy)-2,4,9-trihydroxydibenzo-1,4-dioxin (2), were isolated from Ecklonia Cava. Their ability to inhibit the proliferation of human breast cancer cells were evaluated by measuring cell death via induction of apoptosis. Compound 1 exerted a higher anti-proliferative activity in human breast cancer cells compared with compound 2. Furthermore, compound 1 induced a significant proliferative inhibition and apoptosis in a dose-dependent manner on MCF-7 human cancer cells. Treatment with compound 1 also induced the increase in caspase (-3 and -9) activity, DNA repair enzyme poly-(ADP-ribose) polymerase (PARP) cleavage, and pro-apoptotic gene and the decrease in anti-apoptotic gene. In addition, NF-kappaB family and -dependent activated genes were down-regulated by compound 1. These results indicated that the potential inhibitory effect of compound 1 against growth of MCF-7 human breast cancer cells might be associated with induction of apoptosis through NF-kappaB family and NF-kappaB dependent pathway. The present results suggest that compound 1 has a promising potential to be used as a valuable chemopreventive agent.

PMID:
19393283
DOI:
10.1016/j.fct.2009.04.013
[Indexed for MEDLINE]
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