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Allergy. 2009 Oct;64(10):1478-85. doi: 10.1111/j.1398-9995.2009.02053.x. Epub 2009 Apr 14.

Genetic variation in CRTh2 influences development of allergic phenotypes.

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1
Department of Medicine, Pulmonary Research Group, University of Alberta, Edmonton, Canada.

Abstract

BACKGROUND:

Allergic disorders are characterized by an increase in the Th2 cytokines IL-4, IL-5 and IL-13, produced primarily by Th2 cells. These cells are marked by the expression of CRTh2 (chemoattractant receptor-homologous molecule expressed on Th2 cells), a receptor for prostaglandin D(2). As genetic variation plays a significant role in the predisposition for allergic disorders, we investigated the influence of single nucleotide polymorphisms (SNPs) in CRTh2.

METHODS:

In a large study population of German children (n = 4264) from the International Study of Asthma and Allergy in Children (ISAAC II), six polymorphisms in CRTh2 were genotyped. Statistical analyses were performed using single SNP and haplotype analyses.

RESULTS:

Uncorrected associations among -6373G>A, +1431G>C and +1538A>G were observed with a number of allergic phenotypes (P < 0.05). After correction, association between +1431C and specific IgE to food allergens remained significant (P = 0.04). Associations of haplotype (H)3 (containing +1538G) with reduced risk for asthma and H2 (containing +1431C) with increased risk for specific IgE to food allergens also remained significant after correction for multiple testing (P = 0.004).

CONCLUSIONS:

Genetic variation within CRTh2 modifies the development of allergic sensitization and asthma in a population of German children.

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