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Acta Psychiatr Scand. 2009 Aug;120(2):129-37. doi: 10.1111/j.1600-0447.2009.01386.x. Epub 2009 Mar 31.

Outcomes for 236 patients from a 2-year early intervention in psychosis service.

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1
Totara House Early Intervention for Psychosis Service, Canterbury District Health Board, Christchurch, New Zealand. mark.turner@cdhb.govt.nz

Abstract

OBJECTIVE:

To examine: i) changes in key outcome measures over time in treatment in a representative first-episode psychosis treatment cohort and ii) baseline predictors of service disengagement.

METHOD:

Baseline characteristics of 236 patients were examined for associations with outcomes over time using generalized estimating equation models. The data on disengagement were analysed using logistic regression.

RESULTS:

After controlling for admission scores, patients showed consistently improved outcomes while in treatment on functional recovery (unemployment, P < 0.01; HoNOS, P < 0.001; the Quality of Life Scale, P < 0.001; GAF, P < 0.05) but not symptomatology (as assessed by the PANSS and substance abuse). The 64 (33%) who disengaged were more likely to be unemployed (P < 0.01) and have higher HoNOS (P < 0.01) and GAF (P < 0.05) scores at baseline.

CONCLUSION:

This evaluation has shown significant improvements in psychosocial functioning but not psychopathology during treatment at an Early Intervention for Psychosis Service. Despite attempts to retain patients, there is a high rate of treatment discontinuation.

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