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Nat Rev Clin Oncol. 2009 May;6(5):256-8. doi: 10.1038/nrclinonc.2009.42.

Immunotherapy: Vaccine trials in melanoma -- time for reflection.

Author information

1
Department of Surgical Oncology, Daniel den Hoed Cancer Center, Erasmus University MC, Rotterdam, The Netherlands. a.eggermont@erasmusmc.nl

Abstract

The disappointing results of the large, randomized, controlled trials showing no benefit of vaccines in patients with advanced and metastatic melanoma call for a reassessment of the development of therapeutic vaccines and the importance of better immune monitoring methodology, such as adoptive T-cell therapy with lymphodepletion.

PMID:
19390551
DOI:
10.1038/nrclinonc.2009.42
[Indexed for MEDLINE]

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