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Vaccine. 2009 Jun 19;27(30):4025-30. doi: 10.1016/j.vaccine.2009.04.030. Epub 2009 May 3.

Impact of transmission dynamics on the cost-effectiveness of rotavirus vaccination.

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Department of Epidemiology & Public Health, Yale University School of Medicine, New Haven, CT 06510, USA.


The objective of this study is to estimate the cost-effectiveness of mass vaccination of US infants with the recently available rotavirus vaccine, RotaTeq. We developed a dynamic transmission model of rotavirus to incorporate herd immunity into cost-effectiveness analysis. Our study indicates that a rotavirus vaccination program would prevent about 90% of rotavirus incidence, mortality, hospitalization and emergency department visits annually. We conclude that a universal rotavirus vaccine program in the US would cost $77.30 per case averted from the health care and give a net saving of $80.75 per case averted from the societal perspectives, respectively. The cost per QALY gained was found to be $104,610 when we considered child with one caregiver, making the rotavirus vaccination program a cost-effective intervention.

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