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Dermatol Surg. 2009 May;35(5):765-72. doi: 10.1111/j.1524-4725.2009.01126.x. Epub 2008 Mar 23.

More than 2 decades of treating atypical fibroxanthoma at mayo clinic: what have we learned from 91 patients?

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  • 1Mayo CLinic Rochester, Minnesota 55905, USA.



Atypical fibroxanthoma (AFX) typically occurs on the head and neck of elderly white men. Usually considered a malignancy, it is treated with wide local excision (WLE) or total margin control using Mohs micrographic surgery (MMS).


To determine the most appropriate treatment for this tumor based on a review of cases treated at Mayo Clinic.


We reviewed the medical records of patients with AFX treated at Mayo Clinic from 1980 to 2004.


We identified 91 patients with 93 tumors. Treatment information was available for 88 tumors (59 treated with MMS, 23 with WLE, and 6 by other means). There were no recurrences in the patients treated with MMS, with a median follow-up of 4.5 years (range 1.0-16.1 years). Two patients treated with WLE had single recurrences, with a median follow-up of 8.7 years (range 1.5-26.3 years).


Total microscopic margin control using MMS was the most effective means of treating AFX.

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