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Transfusion. 2009 Jul;49(7):1412-22. doi: 10.1111/j.1537-2995.2009.02151.x. Epub 2009 Mar 31.

Universal adoption of pathogen inactivation of platelet components: impact on platelet and red blood cell component use.

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The Transfusion Center, Cliniques Universitaires de Mont Godinne, Université Catholique de Louvain, Yvoir, Belgium.



Pathogen inactivation of platelet (PLT) components (INTERCEPT Blood System, Cerus Europe) was implemented into routine practice at a blood center supporting a tertiary care hospital. Utilization of platelet components (PCs) and red blood cell (RBC) components was analyzed for 3 years before and 3 years after introduction of pathogen inactivation to assess the impact of pathogen inactivation on component use.


This was a retrospective analysis of prospectively collected data. An electronic database used in routine blood bank hemovigilance to monitor production and use of blood components was analyzed to assess clinical outcomes.


Transfusion records were analyzed for 688 patients supported with conventional PCs and 795 patients supported with pathogen inactivation PCs. Additional analyses were conducted for intensively transfused hematology patients. Patient demographics (age category, sex, and diagnostic category) were not different in the two observation periods. For all patients, mean numbers of PC per patient were not different for conventional PCs and pathogen inactivation PCs (9.9 +/- 19.5 vs. 10.1 +/- 20.9, p = 0.88). Data for hematology patients (272 conventional PCs and 276 pathogen inactivation PCs) confirmed that days of PLT support were not different (31.6 +/- 42.6 vs. 33.1 +/- 47.9, p = 0.70) nor was total PLT dose (10(11)) per patient (87.3 +/- 115.4 vs. 88.1 +/- 111.6, p = 0.93). RBC use, for all patients and hematology patients, was not different in the two observation periods, either during periods of PLT support or outside periods of PLT transfusion support.


Pathogen inactivation of PCs had no adverse impact on component use during a 3-year observation period of routine practice.

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