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Vaccine. 2008 Dec 30;26 Suppl 8:I86-93.

Complement and natural antibody are required in the long-term memory response to influenza virus.

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Immune Disease Institute and Department of Pediatrics and Pathology, Harvard Medical School, 800 Huntington Avenue, Boston, MA 02115, USA.


Complement, complement receptors and natural antibody (IgM) are important factors in the immune response against pathogens. Previous studies have indicated a role for C3, the complement receptors CD35/CD21 (CR1/CR2), and IgM in the immune response to influenza virus. Nevertheless, their contribution to the long-term memory response to this pathogen remains unknown. To elucidate this role, we characterized the secondary response on mice deficient of CR1/CR2 (Cr2-/-), C3 (C3-/-), secreted IgM (micros-/-) and the double knockout C3-/-micros-/-. Overall, our results suggest that C3, IgM and CR1/CR2 play crucial roles in the maintenance of long-term memory to influenza virus, possibly through the development of memory B cells and long-term antibody secretion.

[Indexed for MEDLINE]

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