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J Magn Reson Imaging. 2009 May;29(5):1080-4. doi: 10.1002/jmri.21743.

Microperfusion-induced elevation of ADC is suppressed after contrast in breast carcinoma.

Author information

1
Department of Radiology, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, Kyoto, Japan. syuen@koto.kpu-m.ac.jp

Abstract

PURPOSE:

To investigate the effect of gadolinium (Gd)-DTPA on the apparent diffusion coefficient (ADC) of breast carcinoma and to analyze the relationship between pre/postcontrast ADC and the degree of contrast enhancement.

MATERIALS AND METHODS:

Nineteen histopathologically confirmed breast carcinomas (mean size = 22 mm) were analyzed. Their ADCs before and after contrast administration were measured. The contrast-to-noise ratios (CNRs) of the tumors were measured on fat-suppressed 3D T1-weighted images in precontrast, early, and late postcontrast phases. These results were correlated with the measured ADC values.

RESULTS:

A significant decrease in the measured ADC was noted after contrast administration (-23%, P = 0.01). Lesions with relatively high ADC before contrast (>1.3 x 10(-3) mm(2)/sec; n = 12) demonstrated a larger degree of ADC reduction (mean 34%) than lesions with low ADC (< or =1.3 x 10(-3) mm(2)/sec; n = 7) (mean 4.5%). When an early postcontrast image was used as a surrogate marker of malignant potential, we found a significant inverse correlation with postcontrast ADC (gamma = -0.57, P = 0.02).

CONCLUSION:

Postcontrast ADC exhibited lower values than precontrast ADC, which is thought to reflect suppression of the microperfusion-induced effect on diffusion-weighted imaging. Postcontrast ADC may be a better indicator than precontrast ADC to reflect malignant potential of tumors.

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PMID:
19388115
DOI:
10.1002/jmri.21743
[Indexed for MEDLINE]

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