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Semin Liver Dis. 2009 May;29(2):200-10. doi: 10.1055/s-0029-1214375. Epub 2009 Apr 22.

Similarities and differences in the pathogenesis of alcoholic and nonalcoholic steatohepatitis.

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1
Division of Gastroenterology, Department of Medicine, Duke University Medical Center, Durham, North Carolina 27710, USA.

Abstract

Subpopulations of individuals with alcohol-induced fatty livers and nonalcoholic steatosis develop steatohepatitis. Steatohepatitis is defined histologically: increased numbers of injured and dying hepatocytes distinguish this condition from simple steatosis. The increased hepatocyte death is generally accompanied by hepatic accumulation of inflammatory cells and sometimes increases in myofibroblastic cells, leading to hepatic fibrosis and eventually, cirrhosis. The purpose of this review is to summarize similarities and differences in the pathogenesis of steatohepatitis in alcoholic fatty liver disease and nonalcoholic fatty liver disease.

PMID:
19387919
PMCID:
PMC3644873
DOI:
10.1055/s-0029-1214375
[Indexed for MEDLINE]
Free PMC Article

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