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J Antibiot (Tokyo). 1991 Sep;44(9):925-33.

Structure of aureobasidin A.

Author information

1
Biotechnology Research Laboratories, Takara Shuzo Co., Ltd., Shiga, Japan.

Abstract

Aureobasidin A, a new antifungal antibiotic, was isolated from the culture medium of Aureobasidium pullulans R106. Aureobasidin A was a cyclic depsipeptide consisting of eight alpha-amino acid units and one hydroxy acid unit. The structures of the units were found by acid hydrolysis of the antibiotic to be 2(R)-hydroxy-3(R)-methylpentanoic acid, beta-hydroxy-N-methyl-L-valine, N-methyl-L-valine, L-proline, allo-L-isoleucine, N-methyl-L-phenylalanine, L-leucine, and L-phenyl-alanine. The sequence of the units was identified by NMR and FAB-MS of the products from the alkaline hydrolysis of aureobasidin A.

PMID:
1938614
DOI:
10.7164/antibiotics.44.925
[Indexed for MEDLINE]
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