Format

Send to

Choose Destination
BMC Genomics. 2009 Apr 22;10:175. doi: 10.1186/1471-2164-10-175.

The components of the Daphnia pulex immune system as revealed by complete genome sequencing.

Author information

1
Institute of Evolutionary Biology, University of Edinburgh, Edinburgh, UK. smctagga@staffmail.ed.ac.uk

Abstract

BACKGROUND:

Branchiopod crustaceans in the genus Daphnia are key model organisms for investigating interactions between genes and the environment. One major theme of research on Daphnia species has been the evolution of resistance to pathogens and parasites, but lack of knowledge of the Daphnia immune system has limited the study of immune responses. Here we provide a survey of the immune-related genome of D. pulex, derived from the newly completed genome sequence. Genes likely to be involved in innate immune responses were identified by comparison to homologues from other arthropods. For each candidate, the gene model was refined, and we conducted an analysis of sequence divergence from homologues from other taxa.

RESULTS AND CONCLUSION:

We found that some immune pathways, in particular the TOLL pathway, are fairly well conserved between insects and Daphnia, while other elements, in particular antimicrobial peptides, could not be recovered from the genome sequence. We also found considerable variation in gene family copy number when comparing Daphnia to insects and present phylogenetic analyses to shed light on the evolution of a range of conserved immune gene families.

PMID:
19386092
PMCID:
PMC2685406
DOI:
10.1186/1471-2164-10-175
[Indexed for MEDLINE]
Free PMC Article

Supplemental Content

Full text links

Icon for BioMed Central Icon for PubMed Central
Loading ...
Support Center